Rubiadin 1-methyl ether: A natural photosensitizing anthraquinone with antifungal activity in vitro

MARIONI J; MUGAS M; COMINI L; CABRERA JL; NÚÑEZ MONTOYA SC; PARAJE MG

Córdoba

Otro; Int. J. Pharm. Scs. Res- 3ra REUNIÓN INTERNATIONAL DE CIENCIAS FARMACÉUTICAS; 2014

Facultad Ciencias Químicas, Universidad Nac. Córdoba

Extracts rich in anthraquinones (AQs) of Heterophyllaea pustulata Hook. f. (Rubiaceae), have shown in vitro antifungal effect against planktonic microorganisms. We have established that their purified AQs exhibit photosensitizing activity type I and/or II. Since the most important group of opportunistic fungal pathogens are Candida species, in this study we evaluate the antifungal activity of Rubiadin 1-methyl ehter (RubME), one of the majority AQs from these extracts, against different Candida strains, analyzing whether this effect could be increased by irradiation.