Naturally photosensitizers in photodynamic therapy applied colorectal carcinoma cells using a three dimensional model

GILARDI P; COGNO IS; COMINI LR; CABRERA JL; NUÑEZ MONTOYA S.C.; COMINI L., FERNANDEZ I., MILLA L., NUÑEZ MONTOYA S., CABRERA J., RIVAROLA V.

Mar del Plata

Exposición; Medicina - XLVIII REUNIÓN ANUAL DE SAFE; 2016

Sociedad Argentina de Farmacología Experimental

The history of ethnobotanical studies sho􀁙s that several genera of plants belonging to Argentina can be selected according to their use in traditional medicine as sources of cancer drugs. In our laboratory we have studied photodynamic capacity of different plant compounds called anthraquinones (AQs) in breast cancer cells. These compounds were isolated from a plant called Heterophyllaea pustulata Hook f. (Rubiaceae) growing northwest of Argentina. Photodynamic therapy (PDT) against cancer is the cytotoxic effect induced by the combined action of light and photosensitizing compounds (Fs). Cases have been reported eradication of colorectal cancer (CRC) using PDT as a treatment, but other data show an incomplete response to treatment, presenting long-term recurrence. The aim of this work was to study the effect of photodynamic AQs, such as Rubiadina and Soranjidiol in colorectal carcinoma cells in a three dimensional model