In vitro viral inactivation photosensitized by natural anthraquinones

MUGAS ML; KONIGHEIM BS; AGUILAR JJ; CABRERA JL; CONTIGIANI MS; NÚÑEZ MONTOYA SC

Villa Carlos Paz

Encuentro; XIII ENCUENTRO LATINOAMERICANO DE FOTOQUÍMICA Y FOTOBIOLOGÍA (XIII ELAFOT).; 2017

Grupo Argentino de Fotobiología

From the phototoxic plant, Heterophyllaea pustulata Hook. f. (Rubiaceae), a bush that grows in the Andean northwest of Argentina, we have obtained 9,10-anthraquinone derivatives (AQs) with photosensitizing properties [1-3]. Previously, we have demonstrated that these AQs show in vitro virucidal effect against Herpes Simplex virus Type 1 (HSV-1), which means an inactivation of viral particles before their entry into the host cells, and this inhibition was increased by light action (photostimulation) [4]. The aim of this work was to study the in vitro inactivation of HSV-1 once the virus entered into the host-cells, by the photosensitized action of two natural AQs: soranjidiol (Sor) and 5,5´-bisoranjidiol (Bisor), a soranjidiol dimer.