Human leukemia cells photoinactivation employing an anthraquinone from Argentinean flora

MUGAS M.L.; CALVO G; MARIONI J; VALLECORSA P; CÉSPEDES M; SÁENZ D; DI VENOSA G; NUÑEZ MONTOYA S.C.; CASAS A

Barcelona

Congreso; 17th CONGRESS OF THE INTERNATIONAL UNION OF PHOTOBIOLOGY, 18th CONGRESS OF THE EUROPEAN SOCIETY FOR PHOTOBIOLOGY; 2019

European Society for Photobiology (ESP) and International Union of Photobiology (IUPB).

Parietin (PTN), an anthraquinone (AQ) found in some vegetal species even lichens, has been shown to be a good photosensitizer with promising applications in bacterial photoinactivation. The aim of this work was to evaluate the in vitro activity of PTN as photosensitizer on K562 human leukemic cells; in order to estimate its potential use in Photodynamic Cancer Therapy (PDT).PTN (1,8-dihydroxy-3-methoxy-6-methylanthraquinone) was isolated from the lichen Teoloschistes nodulifer (Nyl.) Hillman (Teloschistaceae) and it was purified by recrystallization from the acetone extract, and its purity was determined by HPLC.