Natural anthraquinones-mediated photodynamic inactivation: preliminary results against Leishmania amazonensis-induced cutaneous leishmaniasis in mice

Viña del Mar

Encuentro; XIV ELAFOT; 2019

Universidad de Santiago de Chile, Universidad Andrés Bello

Cutaneous Leishmaniosis (CL) is one of the 17 neglected tropical disease classified by World Health Organization produced by Leishmania parasites. Following a sandfly bite in exposed areas of skin, a pink papule progresses to a nodule or plaque and eventually forms an ulcer with raised borders. So far, there is no effective treatment without toxicity and resistance.1 Photodynamic inactivation (PDI) appears as a promising topical treatment to overcome this serious health problem. This therapy combines photosensitizers, as natural anthraquinones (AQs), and proper light to produce reactive oxygen species and kill Leishmania parasites.2 A recent in vitro study demonstrated that Soranjidiol (Sor), Bisoranjidiol (Bisor) and 5-Chlorosoranjidiol (5-Clsor) irradiated with LED at 20 J/cm2, reduced above 90% the promastigote viability of Leishmania amazonensis.3 The aim of this work was to conduct a pilot study on infected mice to verify the effect of AQs-mediated PDI on CL.