Changes in Hippocampal Arc Protein Expression and Synaptic Plasticity by

MONTI MARIA CAROLINA; ALMIRON ROMINA SOLEDAD; BIGNANTE ELENA ANAHI; RAMIREZ OSCAR

Wiley-Liss

Año: 2010 p. 39 - 39

font face="AdvP66F9" size="2"> ABSTRACT Contextual cues linked to drug experience have been frequently associated to craving and relapse, with this phenomenon being described in human and experimental animals. Hippocampal synaptic plasticity has been related to learning, memory, and adaptive processes developed during chronic administration of drug abuse. In this study, we investigated if the environmental context associated with withdrawal experience was able to evoke the same behavioral alteration observed after chronic benzodiazepine administration. Furthermore, we studied the hippocampal synaptic plasticity and anatomical expression of Arc protein during withdrawal and the re-exposure to the context associated with anxiety expression (characteristic s