Novel anti-depressant activity in male Wistar rats model of Zn(II)-S-methyl-cysteine complex and others pharmacological activities.

GRACIELA E. ESCUDERO, NAHUEL RAFAEL MARESCA, CARLOS H. LAINO,; NANCY MARTINI, KHALIL JORI, NADIR JORI, PATRICIA A.M. WILLIAMS, EVELINA G. FERRER.

JOHN WILEY & SONS INC

Lugar: New York; Año: 2015

he antidepressant-like effect of simple Zn(II) salts has been proved in several animal models of depression. In this study, a coordination metal complex of Zn(II) having a sulfur containing ligand is tested as antidepressant for the first time. Treatment of Zn(S-Met)2 (S-Met=S-methyl-L-cysteine) in male Wistar rats model shows a decrease in the immobility and the increase in the swimming behavior being this action more effective and remarkable than ZnCl2 (synergic effect as a result of the coordination). This work includes also determination of antioxidant activity and inhibition studies on acid phosphatase enzyme (AcP). Both S-methyl-L-cysteine and Zn(S-Met)2 complex have been proved against peroxyl and hydroxyl radicals. Results present evidence of attenuation of hydroxyl but not peroxyl activity. S-methyl-L-cysteine do not produces effect on AcP activity in contrast to the Zn(S-Met)2 complex that behaves as a good inhibitor agent. Finally, bioavailability studies were performed by