Improving the antidepressant action and the bioavailability of sertraline by co-crystallization with coumarin 3-carboxylate. Structural determination.

ESCUDERO, GE, LAINO CH; ECHEVERRIA GA, PIRO OE, MARTINI N, RODRIGUEZ AN, MEDINA JJM, LOPEZ TEVEZ LL, FERRER EG, WILLIAMS PAM

CHEMICO-BIOLOGICAL INTERACTIONS

ELSEVIER IRELAND LTD

Lugar: Dublin; Año: 2016 vol. 249 p. 46 - 46

0009-2797

he salt generated with protonated sertraline and coumarin 3-carboxylate, for short SerH-CCA, was synthesized and characterized by means of FTIR spectroscopy. The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=11.4045(6) Å, b=8.1812(5) Å, c=12.7394(5) Å, β=91.792(4)°, and Z=2 molecules per unit cell. The pharmacotherapeutic agent sertraline (ser) and the antioxidant compound coumarin 3-carboxylic acid (CCA) appear in the solid as their protonated cationic (SerH+) and deprotonated anionic (CCA-) moieties. The crystal salt is further stabilized by strong intermolecular (Ser) >NH2+?-OOC-(CCA) bonds. The antidepressant effect of the new compound has shown a higher power than sertraline hydrochloride when tested on male Wistar rats.