Effect on Omega-3 Fatty Acids on neurophatic pain in rats following chronic injury of the sciatic nerve

UNDA SANTIAGO R, VILLEGAS EMILCE A, ASIS ONELL GABRIELA, TOLEDO, MARÍA EUGENIA, LAINO CARLOS H

MEDICINA (BUENOS AIRES)

MEDICINA (BUENOS AIRES)

Año: 2017 vol. 77

0025-7680

europathic pain results from an injury or disease of the nervous system (which may be both peripheral and central), and causes the nociceptive system to behave abnormally, with there being a total lack of causal relationship between tissue injury and pain. It is characterized by pain of a spontaneous type and painful hypersensitivity that we can differentiate between allodynia and hyperalgesia.The aim of the present study was to evaluate the potential effect of the use of omega-3 fatty acids (O3) for 21 days on a chronic constriction injury (CCI) model in rats (CCI +O3 group) that induced signs and symptoms which mimicked human conditions of neuropathy. Assessment of nerve regeneration was based on neuropathological examination and histomorphometric criteria, and the thermal heat hyperalgesia was evaluated using the hot plate test (HPT).We found that O3 (720 mg/kg/day) administration increased the response latency significantly compared with the CCI group after 7 days of treatment, w