Inhibition of mouse killing by serotonin mimetic drugs: effects of partial alterations of serotonin neurotransmission

MOLINA VICTOR ALEJANDRO; CIESIELSKI, L.; GOBAILLE, S.; ISEL, F.; MANDEL, P.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1987 vol. 27 p. 123 - 123

ats which do not kill mice and which require mouse killing behavior after partial lesion of the serotonin neurotransmission, either by p-chlorophenylalanine treatment or by electrolytical lesions of dorsal and median raphe nucleus, were treated by IP injection of serotonin-mimetics. The following drugs were used: 5-methoxy-N-N-dimethyl-tryptamine and 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, serotonin-agonists, fluoxetine and citalopram, inhibitors of serotonin uptake. All these serotonin-mimetics inhibit mouse killing behavior without apparent secondary effects. When these compounds were tested on killer rats, a stronger antimuricidal effect was observed in rats having altered serotonin neurotransmission. These results support a role for the serotoninergic supersensitivity in a model of aggressive behavior