Long-term ethanol self-administration induces delta FosB in male and female adolescent, but not in adult, Wistar rats

WILLE-BILLE ARANZA; DE OLMOS SOLEDAD; MARENGO LEONARDO; CHINER FLOR; PAUTASSI RICARDO

PROGRESS OF NEUROPSYCHOPHARMACOLOGY AND BIOLOGICAL PSYCHIATRY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2017 vol. 74 p. 15 - 15

0278-5846

arly-onset ethanol consumption predicts later development of alcohol use disorders. Age-related differences in reactivity to ethanol´s effects may underlie this effect. Adolescent rats are more sensitive and less sensitive than adults to the appetitive and aversive behavioral effects of ethanol, respectively, and more sensitive to the neurotoxic effects of experimenter-administered binge doses of ethanol. However, less is known about age-related differences in the neural consequences of self-administered ethanol. delta FosB is a transcription factor that accumulates after chronic drug exposure and serves as a molecular marker of neural plasticity associated with the transition to addiction. We analyzed the impact of chronic (18 two-bottle choice intake sessions spread across 42 days, session length: 18 h) ethanol [or only vehicle (control group)] self-administration during adolescence or adulthood on the induction of deltaFosB in several brain areas, anxiety-like behavior, and ethanol