Trypanosoma cruzi: immunological cross-reactivity of the major cysteinyl proteinase (cruzipain) with a parasite cytosol acidic antigen (FIV).

CERBAN FM1, MOTRAN C, LADERACH D, GEA S, GRUPPI A, VOTTERO-CIMA E.

ACTA TROPICA

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 1994 vol. 58 p. 337 - 337

0001-706X

is paper shows that a polyclonal monospecific rabbit antiserum to cruzipain, the major T. cruzi cystein proteinase, cross-reacts with a cytosol acidic antigen (F IV) isolated from the epimastigote stage of the same parasite. In addition, antibodies specific for F IV purified from chagasic patient sera or murine anti F IV sera, also react with cruzipain. This was demonstrated by ELISA, DOT-ELISA, native and electrophoretic Immunoblot. These findings suggest that F IV contains an antigen immunologically cross-reactive with cruzipain.