Glycans from Fasciola hepatica Modulate the Host Immune Response and TLR-Induced Maturation of Dendritic Cells

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2015 vol. 31 p. 1 - 1

elminthsexpressvariouscarbohydrate-containingglycoconjugatesontheirsurface, and theyreleaseglycan-richexcretion/secretion productsthatcanbeveryimportantintheirlife cycles,infectionandpathology.Recentevidencesuggeststhatparasiteglycoconjugates couldplayaroleintheevasionoftheimmuneresponse,leadingtoamodifiedTh2-polarizedimmuneresponsethatfavorsparasite survival inthehost.Nevertheless,thereislimitedinformationaboutthenatureorfunctionofglycansproducedbythetrematodeFasciola hepatica,thecausativeagentoffasciolosis.Inthispaper, weinvestigatewhetherglycosylatedmolecules fromF.hepaticaparticipateinthemodulationofhostimmunity.Wealso focusondendriticcells,sincetheyareanimportanttargetofimmune-modulationbyhelminths, affectingtheiractivityorfunction.OurresultsindicatethatglycansfromF.hepatica promotetheproductionofIL-4andIL-10,suppressingIFNγproduction.Duringinfection, thisparasiteisabletoinduceasemi-maturephenotypeofDCsexpressing lowlevelsof MHCIIandsecreteIL-10.Furthermore,weshowthatparasit