Indoleamine 2,3 Dioxigenase (IDO) is critical for the host resistance against Trypanosoma cruzi.

KNUBEL, CP,.MARTÍNEZ FF, FRETES RE, DÍAZ LUJAN C, THEUMER M CERVI L AND MOTRÁN CC

FEDERATION AMER SOC EXP BIOL

Año: 2010

b> ABSTRACT Indoleamine 2,3-dioxigenase (IDO) is an inflammatory cytokine-inducible rate-limiting enzyme of the tryptophan (Trp) catabolism, which is involved in the inhibition of intracellular pathogen replication as well as in immunomodulation. Here we demonstrated the effect of IDO-dependent Trp catabolism on Trypanosoma cruzi resistance to acute infection. Infection with