Excretory-secretory products (ESP) from Fasciola hepatica induce

C FALCÓN, F CARRANZA, FF. MARTÍNEZ, C. KNUBEL, DT. MASIH, C MOTRAN AND L CERVI

ELSEVIER SCIENCE BV

Año: 2010

font face="GulliverIT" color="#231f20" size="1"> Fasciola hepatica is a helminth trematode that migrates through the host tissues until reaching bile ducts where it becomes an adult. During its migration the parasite releases different excretory-secretory products (ESP), which are in contact with the immune system. In this study, we focused on the effect of ESP on the maturation and function of murine bone marrow derived-dendritic cells (DC). We found that the treatment of DC with ESP failed to induce a classical maturation of these cells, since ESP alone did not activate DC to produce any cytokines, althou