Resumen:
asciola hepatica is a worldwide distributed helminth pathogen that causes great economic losses in sheep and
cattle. This parasite is able to regulate the host immune response, producing high levels of IL-5 and low levels of
IFNγ, as well as modulating the function of dendritic cells (DCs), mast cells or macrophages, among others.
Moreover, TLR-mediated maturation of DCs can be suppressed by F. hepatica derived components. Here, we
investigated the role of glycans in the modulation of LPS-induced maturation of DCs, as well as in the production of
IL-5 and IFNγ by splenocytes from infected mice. We show that F. hepatica induces the recruitment to the
peritoneum of semi-matured DCs, as judged by a down-regulation of MHC class II molecule expression and an
increase of CD80 and CD86 expression of DCs in the peritoneum of infected animals. Furthermore, we provide
evidence indicating that glycan structures from F. hepatica are responsible, at least in part, for inhibiting