CERVI LAURA
Artículos
Título:
PD-L2 negatively regulates Th1-mediated immunopathology during Fasciola hepatica infection
Autor/es:
STEMPIN CINTHIA; CLAUDIA C. MOTRÁN ; AOKI PILAR; FALCÓN CRISTIAN; CERBAN F; CERVI, LAURA
Revista:
oncotarget
Editorial:
Elsevier
Referencias:
Año: 2016 vol. 7 p. 77721 - 77721
Resumen:
acrophage plasticity is critical for controlling inflammation including thoseproduced by helminth infections, where alternatively activated macrophages (AAM)are accumulated in tissues. AAM expressing the co-inhibitory molecule programmeddeath ligand 2 (PD-L2), which is capable of binding programmed death 1 (PD-1) expressed on activated T cells, have been demonstrated in different parasiticinfections. However, the role of PD-L2 during F. hepatica infection has not yet beenexplored. We observed that F. hepatica infection or a F. hepatica total extract (TE)injection increased the expression of PD-L2 on peritoneal macrophages. In addition,the absence of PD-L2 expression correlated with an increase in susceptibility to F.hepatica infection, as evidenced by the shorter survival and increased liver damageobserved in PD-L2 deficient (KO) mice. We assessed the contribution of the PD-L2pathway to Th2 polarization during this infection, and found that the absence of PD-L2caused a diminished Th2