Resumen:
hagas cardiomyopathy is the consequence of acompromised electrical and mechanical cardiac function, withparasite persistence, unbalanced inflammation, and pathologicaltissue remodelling, being intricately related to myocardial aggressionand impaired function. Recent studies have shown that Wnt signalingpathways play a critical role in the pathogenesis of cardiac andvascular diseases. In addition, we have reported that Trypanosomacruzi infection activates Wnt signaling to promote intracellularreplication of the parasites in macrophages, with the treatment ofmice with IWP-L6 (an inhibitor of the O-acyl-transferase, PORCN,responsible for the post-translational modifications necessary for Wntprotein secretion) being able to diminish parasitemia and tissueparasitism. Here, we show that inhibition of Wnt signaling during theacute phase of T. cruzi infection controls the parasite replication, inhibits the development of parasite-prone and fibrosis-prone Th2-type immune response, and prevents