Dendritic cells and parasites: from recognition and activation to immune response instruction

MOTRAN, CLAUDIA CRISTINA; AMBROSIO, LAURA FERNANDA; VOLPINI, XIMENA; CELIAS, DAIANA PAMELA; CERVI, LAURA

SEMINARS IN IMMUNOPATHOLOGY

SPRINGER

Año: 2017 vol. 39 p. 199 - 199

1863-2297

he effective defense against parasite infections requires the ability to mount an appropriate and controlled specific immune response able to eradicate the invading pathogen while limiting the collateral damage to self-tissues. Dendritic cells are key elements for the development of immunity against parasites; they control the responses required to eliminate these pathogens while maintaining host homeostasis. Ligation of dendritic cell pattern recognition receptors by pathogen-associated molecular pattern present in the parasites initiates signaling pathways that lead to the production of surface and secreted proteins that are required, together with the antigen, to induce an appropriate and timely regulated immune response. There is evidence showing that parasites can influence and regulate dendritic cell functions in order to promote a more permissive environment for their survival. In this review, we will focus on new insights about the ability of protozoan and helminth parasites o