Early cognitive impairment associated with a parkinsonian animal model: synaptic plasticity and initial approaches with IGF-1 gene therapy

HERRERA MACARENA LORENA; OTAMENDI ANDREA; CHAMPARINI LEANDRO GABRIEL; CALFA GASTÓN DIEGO; BELLINI MARÍA JOSÉ; MOLINA VICTOR ALEJANDRO; HEREÑÚ CLAUDIA BEATRIZ

Córdoba Capital

Jornada; VII Jornadas de Posgrado - II Jornadas de Ciencia y Tecnología; 2018

Facultad de Ciencias Químicas

Parkinson´s disease (PD) is a neurodegenerative disorder that results from a progressive dopaminergic neuronal loss. It is considered a multifactorial condition due to the multiplicity of symptoms experienced by patients. While this condition is known for its characteristic motor deficits, patients also have wide variety of non-motor symptoms, such as impaired learning and memory deficits, which severely affect their quality of life. These non-motor symptoms result from the dysfunction of interconnected systems, including the striatum, the neocortex and the hippocampus. Growth factors are new targets for therapeutical approaches. Insulin-like growth factor-1 (IGF-1) is an endogenous peptide transported across the blood brain barrier that is protective in several brain injury models, including in an animal model of parkinsonism.