Molecular mechanisms underlying promotor effect of IGF-1 on the formation of a fear memory trace

CHAMPARINI LEANDRO GABRIEL; HERRERA MACARENA LORENA; ESPEJO PABLO JAVIER; OTAMENDI ANDREA; COMAS MUTIS RAMIRO GABRIEL; CALFA GASTÓN DIEGO; MOLINA VICTOR ALEJANDRO; HEREÑÚ CLAUDIA BEATRIZ

Villa Carlos Paz

Congreso; XXXIV Congress of the Argentine Society for Research in Neuroscience; 2019

Sociedad Argentina de Neurociencias

It is well known that exposure to an aversive experience (traumatic event) generates the development of a negative emotional state. This state ismanifested, among other behaviors, by the expression of excessive emotional responses as an increase in fear and anxiety, in a variety of animalmodels. At the time it has been described a cerebral circuit that is involved in the generation of such emotional state, basolateral amygdala complex(BLA) plays an essential role in the generation of this state. This structure participates in the modulation within different brain areas such as thedorsal hippocampus. Insulin-like growth factor I (IGF-I) would facilitate hippocampal circuits in terms of plasticity and synaptic structure, andparticipate in neurogenic aspects modifying learning, memory and cognitive functionality. Knowledge of this will allow elucidate the molecularmechanisms involved in the storage of aversive experiences an understand some psychopathologies related to traumatic memories.