Dorsolateral Entorhinal Cortex in the destabilization/reconsolidation process of Fear Memories

COMAS MUTIS, RAMIRO GABRIEL; CALFA, GASTÓN DIEGO

Virtual

Congreso; Reunión Anual de la SAN 2021; 2021

Sociedad Argentina de Investigación en Neurociencias

The Dorsal Hippocampus (DH) and the basolateral complex of the Amygdala (BLA) are brain structures critically involved in the destabilization/reconsolidation process. Interestingly, BLA exerts a modulatory role over the structural plasticity of DH during said process. However,there is no direct connection between the two structures. The entorhinal cortex, particularly the dorsolateral region (dl-CEnt) is a parahippocampal structure regarded as the main input of the Hippocampus, and potentially an operational intermediate for the emotional informationbetween both brain areas. In the present work we explored the role of the dl-CEnt, trough pharmacological manipulation, in the destabilization/reconsolidation of fear memories as a step in outlining and further understanding the neural circuit between BLA and DH.