Cytotoxic activity of extracts from plants of central Argentina on sensitive and multidrug-resistant leukemia cells. Isolation of an active principle from Gaillardia megapotamica.

MARÍA LAURA GONZÁLEZ; MARIANA BELÉN JORAY; JERÓNIMO LAIOLO; MARÍA INÉS CRESPO; SARA MARÍA PALACIOS; GUSTAVO MIGUEL RUIZ; MARÍA CECILIA CARPINELLA

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

OXFORD UNIV PRESS

Lugar: Oxford; Año: 2018

1741-427X

lants are a significant reservoir of cytotoxic agents, including compounds with the ability to interfere with multidrug-resistant (MDR) cells. With the aim of finding promising candidates for chemotherapy, 91 native and naturalized plants collected from the central region of Argentina were screened for their cytotoxic effect toward sensitive andMDR P-glycoprotein (P-gp) overexpressing human leukemia cells by means of MTT assays. The ethanol extracts obtained from Aldama tucumanensis, Ambrosia elatior, Baccharis artemisioides, Baccharis coridifolia, Dimerostemma aspilioides, Gaillardia megapotamica, and Vernonanthura nudiflorapresented outstanding antiproliferative activity at 50 𝜇g/mL, with inhibitory values from 93 to 100%, when tested on the acute lymphoblastic leukemia (ALL) cell line CCRF-CEM and the resistant derivative CEM-ADR5000, while 70?90% inhibition was observed against the chronicmyelogenous leukemia (CML) cell K562 and its corresponding resistant subline, Lucena