Crystallographic, thermal and spectroscopic characterization of a ciprofloxacin saccharinate polymorph.

ROMAÑUK CAROLINA BEATRIZ; GARRO LINCK YAMILA; CHATTAH ANA KARINA; MONTI GUSTAVO; CUFFINI SILVIA LUCIA; GARLAND MARÍA TERESA; BAGGIO ROBERTO; MANZO RUBEN HILARIO; OLIVERA MARÍA EUGENIA

INTERNATIONAL JOURNAL OF PHARMACEUTICS

Elsevier

Año: 2010 vol. 391 p. 197 - 197

0378-5173

new polymorphic form of ciprofloxacin saccharinate (CIP-SAC II) is presented, and compared with CIP-SAC I, a different polymorph which we had previously reported. The characterization techniques used were single crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetry analysis and infrared and 13C solid-state nuclear magnetic resonance spectroscopy. The results obtained from these techniques are consistent. Differential scanning calorimetry and thermogravimetric analysis showed that the reaction between the precursors is completed and the crystalline forms of both salts obtained (I and II) are highly pure. Infrared spectroscopy gave clear evidence of a salt formation. Solid state nuclear magnetic resonance spectroscopy would indicate some degree of qualitative similarity in the intermolecular interaction scheme in both polymorphs, while thermal analysis data might indicate a difference in quantitative terms. A thorough single crystal structure determi