ROMAÑUK CAROLINA BEATRIZ
Artículos
Título:
Analgesia enhancement and prevention of tolerance to morphine: beneficial effects of combined therapy with omega-3 fatty acids
Autor/es:
ESCUDERO GRACIELA; ROMAÑUK CAROLINA BEATRIZ; TOLEDO MARÍA EUGENIA; OLIVERA MARÍA EUGENIA; MANZO RUBEN HILARIO; LAINO CARLOS HORACIO
Revista:
JOURNAL OF PHARMACY AND PHARMACOLOGY
Editorial:
PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN
Referencias:
Año: 2015 vol. 67 p. 1251 - 1251
ISSN:
0022-3573
Resumen:
bjectives Recent evidence associates omega-3 fatty acids (O3) with pain reduction.The aim of this work was to evaluate the antinociceptive effect of O3, eitheralone or in combination with morphine after acute and chronic administration inrats. As well, a new pharmaceutical mixture that allows the concomitant administrationof O3 and morphine as an oral solution was developed.Methods Animals were fed on a control or an experimental diet supplementedwith O3. They were subjected to the hot-plate test to assess analgesic effect andtolerance to the analgesic effect of morphine. The open-field test was carried outto determine if the differences in the response latency can be related to nonspecificsedative effects.Key findings O3 dietary supplementation increased the response latency comparedwith the control group. Acute treatment with morphine in these groupsresulted in an additive antinociceptive effect not related to locomotor activity.Chronic coadministration of morphine with O3 attenuate