Polymorphism in a new ciprofloxacin saccharinate: X-Ray, FTIR and Solid State NMR characterization

ROMAÑUK CAROLINA BEATRIZ; GARRO LINCK YAMILA; CHATTAH ANA KARINA; MONTI GUSTAVO ALBERTO; BAGGIO ROBERTO; GARLAND MARÍA TERESA; CUFFINI SILVIA LUCIA; MANZO RUBEN HILARIO; OLIVERA MARÍA EUGENIA

San Pedro, Brasil

Simposio; II Simpósio Latino Americano de Polimorfismo e Cristalização em Fármacos e Medicamentos-LAPOLC 2009; 2009

LAPOLC

A new polymorphic form of Ciprofloxacin saccharinate (CIP-SAC form II) was obtained in a single crystal form. The product was characterized, and compared with our previously reported form I. To distinguish both polymorphic forms we used X-ray powder diffraction, single-crystal X-ray diffraction, Infrared and Solid State NMR (13C-CPMAS). DSC/TGA showed that the reaction between precursors is complete and the crystals are obtained with a high degree of purity. Both forms I and II are obtained as salts, as can be observed from the FTIR spectroscopy. Powder X-ray diffraction and 13C CP-MAS allow distinguishing the two polymorphic forms. Single crystal X-ray diffraction of form II accounted for inter and intra molecular interactions which could be extrapolated to form I.