Swellable anti-tubercular drug-polyelectrolyte matrices: characterization and delivery properties

LUCIANI GIACOBBE LAURA CAROLINA; RAMÍREZ RIGO MARÍA VERÓNICA; CATANI YANINA; ROMAÑUK CAROLINA BEATRIZ; MANZO RUBEN HILARIO; OLIVERA MARÍA EUGENIA

Córdoba

Otro; 1ª Reunión Internacional de Ciencias Farmacéuticas-RICiFa; 2011

Facultad de Ciencias Químicas-UNC

Rifampicin (RIF) and Isoniazid (INH) are administered in Fixed Dose Combination (FDC) solid formulations to improve patient compliance in the treatment of tuberculosis. In FDC, RIF bioavailability problems are frequent because of its acid decomposition, catalyzed by INH. RIF degradation is proportional to INH concentration in acidic media. These problems could be overcome by developing an FDC in which the delivery of the drugs is site-specific and segregated, with RIF released in stomach and INH in small intestine. The aim of this work is to obtain and characterize swellable drug-polyelectrolyte matricial systems of RIF and INH for a further development of a bi-layer tablet that sequentially release RIF and INH.