ROMAÑUK CAROLINA BEATRIZ
Congresos y reuniones científicas
Título:
Polymorphism in a new ciprofloxacin saccharinate: X-Ray, FTIR and Solid State NMR characterization.
Autor/es:
ROMAÑUK CAROLINA BEATRIZ; GARRO LINCK YAMILA; CHATTAH ANA KARINA; MONTI CUSTAVO; BAGGIO ROBERTO; GARLAND MARÍA TERESA; CUFFINI SILVIA LUCIA; MANZO RUBEN HILARIO; OLIVERA MARÍA EUGENIA
Lugar:
Córdoba
Reunión:
Jornada; IV Jornadas de Postgrado de la Facultad de Ciencias Químicas-UNC.; 2009
Institución organizadora:
Departamento de Postgrado, FCQ-UNC
Resumen:
Polymorphism has been recognized as an important element of drug development.1 Ciprofloxacin (CIP) is a widely prescribed broad-spectrum oral antibiotic for the treatment of infections2. Saccharin (SAC) is one of the best known and most widely used artificial sweetening agents. Also, it could be used to improve organoleptic properties of drugs. New pharmaceutical derivatives of CIP with SAC having sweet taste, have been recently reported.3
In the present work we characterize the CIP-SAC form II (Fig 1), which is compared with the previously reported form I.3 CIP-SAC (II) was successfully obtained as a single-crystal.
To characterize both polymorphic forms we used solid state techniques: powder X-ray diffraction, single-crystal X-ray diffraction, Infrared and Solid State NMR.
CIP-SAC (II) was studied and compared with form I previously reported. The solid state techniques used in this work allow the successful characterization of polymorphic forms of pharmaceutically relevant compounds in solid state.
In the present work we characterize the CIP-SAC form II (Fig 1), which is compared with the previously reported form I.3 CIP-SAC (II) was successfully obtained as a single-crystal.
To characterize both polymorphic forms we used solid state techniques: powder X-ray diffraction, single-crystal X-ray diffraction, Infrared and Solid State NMR.
CIP-SAC (II) was studied and compared with form I previously reported. The solid state techniques used in this work allow the successful characterization of polymorphic forms of pharmaceutically relevant compounds in solid state.
