ROMAÑUK CAROLINA BEATRIZ
Congresos y reuniones científicas
Título:
Polymorphism in a new ciprofloxacin saccharinate: X-Ray, FTIR and Solid State NMR characterization.
Autor/es:
ROMAÑUK CAROLINA BEATRIZ; GARRO LINCK YAMILA; CHATTAH ANA KARINA; MONTI CUSTAVO; BAGGIO ROBERTO; GARLAND MARÍA TERESA; CUFFINI SILVIA LUCIA; MANZO RUBEN HILARIO; OLIVERA MARÍA EUGENIA
Lugar:
San Pedro
Reunión:
Simposio; II Simpósio Latino Americano de Polimorfismo e Cristalização em Fármacos e Medicamentos.; 2009
Institución organizadora:
LAPOLC
Resumen:
Polymorphism has been recognized as an important element of drug development.1 The fluoroquinolone Ciprofloxacin (CIP) is a widely prescribed broad-spectrum oral antibiotic available in more than 100 countries and has been approved for the treatment of several types of infections2. Saccharin (SAC) is one of the best known and most widely used artificial sweetening agents. Also, it has been proposed that it could be used to improve organoleptic properties of drugs. New pharmaceutical derivatives of fluoroquinolones with SAC having sweet taste, have been recently reported.3
In the present work we characterize the CIP-SAC form II (Fig 1 and 2), which is compared with the previously reported form I.3 CIP-SAC (II) was successfully obtained as a single-crystal.
To characterize and distinguish both polymorphic forms we used solid state techniques: powder X-ray diffraction, single-crystal X-ray diffraction, Infrared and Solid State NMR (13C-CPMAS).
In the present work we characterize the CIP-SAC form II (Fig 1 and 2), which is compared with the previously reported form I.3 CIP-SAC (II) was successfully obtained as a single-crystal.
To characterize and distinguish both polymorphic forms we used solid state techniques: powder X-ray diffraction, single-crystal X-ray diffraction, Infrared and Solid State NMR (13C-CPMAS).
