Resumen:
ntroduction: Cyclodextrins (CD), are known to form inclusion complexes with a variety of guest moleculesboth in solution and in the solid state. This can lead to the alteration of properties of guest molecules.Unfortunately, the complexation efficiency of CD is rather low, and can be enhanced by formationof ternary complexes using aminoacids (AA). Sulfadiazine (SDZ) is an antibiotic with extremely lowwater solubility which limits its therapeutic applications and bioavailability.Objetives: The aim of this work was to increase the aqueous solubility of SDZ by preparing ternarycomplexes of this drug with β-cyclodextrin (βCD) and an AA as a third auxiliary substance.Materials y Methods: Complex formation was studied by phase solubility analysis (PSA), nuclear magneticresonance (NMR), differential scanning calorimetry (DSC), thermogravimetric analysis (TG) andscanning electron microscopy (SEM).Results: The apparent stability constants (KC) of the multicomponent complexes were cal