Resumen:
ovel complexes of two different solid forms of Albendazol and -cyclodextrin were investigated in anattempt to obtain promising candidates for the preparation of alternative matrices used in pharmaceuticaloral formulations. The interaction between each form of Albendazol and -cyclodextrin was studied insolution and solid state, in order to investigate their effect on the solubility and dissolution rate of Albendazolsolid forms. The solid supramolecular systems were characterized using a variety of techniquesincluding natural-abundance 13C cross-polarization magic-angle-spinning nuclear magnetic resonance,powder X-ray diffraction, Fourier transform-infrared spectroscopy and scanning electron microscopy.The results obtained showed the highest increment of solubility and dissolution rate, in simulated gastricfluid, for the Albendazole II:-cyclodextrin systems. Thus, these new complexes constitute an interestingalternative for improving the oral bioavailability of Albendazol.