Enalapril:b-CD complex: stability enhancement in solid state.

ARIANA ZOPPI; CLAUDIA GARNERO; YAMILA GARRO LINCK; ANA K. CHATTAH; GUSTAVO A. MONTI; MARCELA R. LONGHI

ELSEVIER SCI LTD

Año: 2011 vol. 86 p. 716 - 716

omplexation of enalapril maleate with b-cyclodextrin was used to overcome the known enalapril maleate?excipient interaction in solid state. The complex formation was characterized by 13C solid state nuclear magnetic resonance, X-ray powder diffraction and scanning electron microscopy. Additionally, thermogravimetric analysis (TGA) was used to evaluate the compatibility between magnesium stearate with enalapril maleate alone or in the complex form. Degradation of the drug at 40 °C/75% relative humidity in the presence of magnesium stearate was monitored by high performance liquid chromatography (HPLC). Enalapril maleate