GARRO LINCK YAMILA
Congresos y reuniones científicas
Título:
Polymorphism in a new ciprofloxacin saccharinate: X-Ray, FTIR and solid state NMR characterization.
Autor/es:
C. B. ROMAÑUK; YAMILA GARRO LINCK; ANA K. CHATTAH; GUSTAVO A. MONTI; R. BAGGIO; M. T. GARLAND; S. L. CUFFINI; RUBÉN H. MANZO; MARÍA E. OLIVERA
Lugar:
Estancia San Pedro, Brasil
Reunión:
Simposio; II Latin- American Symposium on Polymorphism and Crystallization in Drugs and Medicines LAPOLC 09; 2009
Resumen:
A new polymorphic form of Ciprofloxacin saccharinate (CIP-SAC form II) was obtained in a single crystal form. The product was
characterized, and compared with our previously reported form I. To distinguish both polymorphic forms we used X-ray powder
diffraction, single-crystal X-ray diffraction, Infrared and Solid State NMR (13C-CPMAS). DSC/TGA showed that the reaction
between precursors is complete and the crystals are obtained with a high degree of purity. Both forms I and II are obtained as
salts, as can be observed from the FTIR spectroscopy. Powder X-ray diffraction and 13C CP-MAS allow distinguishing the two
polymorphic forms. Single crystal X-ray diffraction of form II accounted for inter and intra molecular interactions which could be
extrapolated to form I.
characterized, and compared with our previously reported form I. To distinguish both polymorphic forms we used X-ray powder
diffraction, single-crystal X-ray diffraction, Infrared and Solid State NMR (13C-CPMAS). DSC/TGA showed that the reaction
between precursors is complete and the crystals are obtained with a high degree of purity. Both forms I and II are obtained as
salts, as can be observed from the FTIR spectroscopy. Powder X-ray diffraction and 13C CP-MAS allow distinguishing the two
polymorphic forms. Single crystal X-ray diffraction of form II accounted for inter and intra molecular interactions which could be
extrapolated to form I.
