Compact On-Line Flow-Through NMR Spectroscopy to Monitor Chemical Reactions

MARIO H. M. KILLNER; YAMILA GARRO LINCK; ERNESTO DANIELI; BERNHARD BLÜMICH

Conferencia; 54th ENC Conference; 2013

Mobile NMR spectroscopy in combination with flow setups is an attractive option to monitor and control chemical processes. By providing chemical information in real time, it is possible to adjust the reaction parameters to save time and resources and to optimize product quality. In this work we 1H NMR spectra were measured with a compact 1 T magnet under the fume hood in real time in a flow-through set-up to study different chemical reactions, such as the transfer hydrogenation of acetophenone to 1-phenylethanol or the base-catalyzed transesterification of vegetable oils with a short chain alcohol to produce biodiesel. For each case, the effects of type of flow, flow rates, concentrations, cell characteristics and tubing lengths are discussed for optimum observation of the reaction.