Cryptococcus neoformans glucuronoxylomannan induces macrophage apoptosis mediated by nitric oxide in a caspase-independent pathway.

CHIAPELLO, LS; BARONETTI, JL; GARRO, AP; SPESSO, F; MASIH, DT

Oxford Journals

Año: 2008 vol. 20 p. 1527 - 1527

font size="1" face="AdvPSHEL-B"> Glucuronoxylomannan (GXM) is the major component of Cryptococcus capsular polysaccharide, which represents an essential virulence factor for this yeast. Cryptococcus neoformans infections in immunocompetent rats are associated with inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production by macrophages. This study demonstrates in vitro and