Immunization with crude antigens plus aluminium hydroxide protects cattle from Fasciola hepatica infection

GUASCONI, L; SERRADELL, MC; BORGONOVO, J; GARRO, AP; VARENGO, H; CAFFE, G; MASIH, DT

CAMBRIDGE UNIV PRESS

Año: 2011 p. 1 - 1

font size="2" face="AdvPS7C2E"> The ability of total homogenate (TH) of Fasciola hepatica conjugated with aluminium hydroxide (alum) or Freund?s complete adjuvant (FCA) to protect cattle against experimental fasciolosis was evaluated. Compared with the infected group, the immunized animals with alum-TH and FCA-TH presented a significant reduction in fluke burden (85.9% and 96.8%, respectively), a higher percentage of short-sized worms, a marked reduction in the released eggs in faeces (89% and 57%, respectively), as well as an increased production of specific antibodies before infection. The alum-TH immunized group also showed a signif