Rat eosinophils stimulate the expansion of Cryptococcus neoformans-specific CD4+ and CD8+ T cells with a Th1 profile

GARRO, AP; CHIAPELLO, LS; BARONETTI, JL; MASIH, DT

WILEY-BLACKWELL PUBLISHING, INC

Año: 2011 vol. 132 p. 174 - 174

p style="TEXT-ALIGN: justify; LINE-HEIGHT: 200%; MARGIN: 0cm 0cm 0pt" class="MsoNormal">Experimental Cryptococcus neoformans infection in rats has been shown to have similarities with human cryptococcosis, revealing a strong granulomatous response and a low susceptibility to dissemination. Moreover, it has been shown that eosinophils are components of the inflammatory response to C. neoformans infections. In this in vitro study, we demonstrate that rat peritoneal eosinophils phagocytose opsonized-live yeasts of C. neoformans, and that phenomenon involves the engagement of Fc