Eosinophils elicit proliferation of naive and fungal-specific cells in vivo so enhancing a Th1 cytokine profile in favor of a protective immune response against C. neoformans infection

GARRO, AP; CHIAPELLO, LS; BARONETTI, JL; MASIH, DT

WILEY-BLACKWELL PUBLISHING, INC

Año: 2011 vol. 134 p. 198 - 198

p style="TEXT-ALIGN: justify; LINE-HEIGHT: 200%; MARGIN: 0cm 0cm 0pt" class="MsoNormal">Experimental Cryptococcus neoformans infection in rats has been shown to have similarities with human cryptococcosis, because as in healthy humans, rats can effectively contain cryptococcal infection. Moreover, it has been shown that eosinophils are components of the immune response to C. neoformans infections. In a previous in vitro study, we demonstrated that rat peritoneal eosinophils phagocytose opsonized live yeasts of C. neoformans, thereby triggering their activation, as indicated by the up-regulation of MHC and co-stimulatory molecules and the increase in IL-12, TNF