Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld Method

L. S. BERNARDI; F. B. FERREIRA; S. CUFFINI; C. E. MADURO DE CAMPOS; G. A. MONTI; G. KUMINEK; P. R. OLIVEIRA; S. G. CARDOSO

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2013 vol. 117 p. 189 - 189

enlafaxine hydrochloride(VEN)isanantidepressantdrugwidelyusedforthetreatmentofdepression. The purposeofthisstudywastocarryoutthepreparationandsolidstatecharacterizationofthepure polymorphs (Forms1and2)andthepolymorphicidentification andquantification offourcommercially- availableVENrawmaterials.Thesetwopolymorphicformswereobtainedfromdifferentcrystallization methods andcharacterizedbyX-rayPowderDiffraction(XRPD),DiffuseReflectance InfraredFourier Transform(DRIFT),RamanSpectroscopy(RS),liquidandsolidstateNuclearMagneticResonance(NMR and ssNMR)spectroscopies,DifferentialScanningCalorimetry(DSC),andScanningElectronMicroscopy (SEM) techniques.ThemaindifferenceswereobservedbyDSCandXRPDandthelatterwaschosenas the standardtechniquefortheidentification andquantification studiesincombinationwiththeRietveld method forthecommercialrawmaterials(VEN1?VEN4) acquiredfromdifferentmanufacturers. AdditionallyForm1andForm2canbeclearlydistinguishedfromtheir 13C ssNMRspectra.Through the analysi