Physicochemical characterization of deflazacort: Thermal analysis, crystallographic and spectroscopic study

S. L. CUFFINI; J. F. ELLENA; Y. P. MASCARENHAS; A. P. AYALA; H. W. SIELSER; J. M. FILHO; G. A. MONTI; V. AIASSA; N. R. SPERANDEO

STEROIDS

Elsevier Inc.

Año: 2007 vol. 72 p. 261 - 261

0039-128X

p style="LINE-HEIGHT: 150%; TEXT-ALIGN: justify">The solid state properties of deflazacort (1-(1,16)-21-(acetyloxy)-11-hydroxy-2-methyl-5H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 1) were investigated using differential scanning calorimetry (DSC), thermogravimetry (TG), single-crystal X-ray diffraction, solid and liquid nuclear magnetic resonance spectroscopy (13C NMR), Fourier transform infrared and Raman spectroscopy (FTIR and FT Raman). From the trends observed in the crystal structure and spectral data some conclusions can be made about hydrogen bonding