NMR and IR characterization of the aluminium complexes of norfloxacin and ciprofloxacin fluoroquinolones

A. K. CHATTAH; Y. GARRO LINCK; G. A. MONTI; P. R. LEVSTEIN; S. BREDA; R. H. MANZO; M. E. OLIVERA

MAGNETIC RESONANCE IN CHEMISTRY

Wiley UK

Año: 2007 vol. 45 p. 850 - 850

0749-1581

p style="TEXT-ALIGN: justify">A set of new aluminium complexes of norfloxacin (NOR) and ciprofloxacin (CIP) that shows an improvement in their pharmaceutical properties were studied using solution and solid state Nuclear Magnetic Resonance (NMR) and infrared (IR) spectroscopy. The complexes synthesized with two different methods were compared. One of these methods will allow to formulate the compounds at production scale. High resolution 13C spectra were obtained with the cross polarization and magic angle spinning (CP-MAS) experiment. These spectra were assigned by comparing with the solution data of the pure drug and by using a quaternary carbon edition technique. The carbon relaxation times in the rotating frame, T1rC