Crystallographic, thermal and spectroscopic characterization of a ciprofloxacin saccharinate polymorph

C. B. ROMAÑUK; Y. GARRO LINCK; A. K. CHATTAH; G. A. MONTI; S CUFFINI; M. T. GARLAND; R. BAGGIO; R. H. MANZO; M. E. OLIVERA

ELSEVIER SCIENCE BV

Año: 2010 vol. 391 p. 197 - 197

font face="GulliverRM" size="1"> A new polymorphic form of ciprofloxacin saccharinate (CIP-SAC II) is presented, and compared with CIPSAC I, a different polymorph which we had previously reported. The characterization techniques used were single crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetry analysis and infrared and 13C solid-state nuclear magnetic resonance spectroscopy. The results obtained from these techniques are consistent. Differential scanning calorimetry and thermogravimetric analysis showed that the reaction between the precursors is completed and the crystalline forms of both salts obtained (I and II) are highly pure.