Polymorphism has been recognized as an important element of drug development.1 The fluoroquinolone Ciprofloxacin (CIP) is a widely prescribed broad-spectrum oral antibiotic available in more than 100 countries and has been approved for the treatment of several types of infections2. Saccharin (SAC) is one of the best known and most widely used artificial sweetening agents. Also, it has been proposed that it could be used to improve organoleptic properties of drugs. New pharmaceutical derivatives of fluoroquinolones with SAC having sweet taste, have been recently reported.3
|
To characterize and distinguish both polymorphic forms we used solid state techniques: powder X-ray diffraction, single-crystal X-ray diffraction, Infrared and Solid State NMR (13C-CPMAS).