Chitosan induces different L-arginine metabolic pathways in resting and inflammatory macrophages

C. PORPORATTO; I.D. BIANCO; C.M. RIERA; S.G. CORREA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Elsevier

Año: 2003 vol. 304 p. 266 - 266

0006-291X

font lang="en" face="AdvPSTim" size="1"> Chitosan is a linear polymer of N-acetyl-D-glucosamine and deacetylated glucosamine widely used as a wound-healing accelerator in clinical and veterinary medicine. Chitosan enhances the functions of inflammatory cells such as macrophages (M/), inducing the production of cytokines as well as the expression of activation markers, Fc receptors and mannose receptor. In this work we studied the effects of chitosan on the arginine metabolic pathways of both resident and inflammatory (proteose–peptone elicited) rat M/.