POLYISOPRENE MATRIX FOR PROGESTERONE RELEASE: IN VITRO AND IN VIVO STUDIES

V. HEREDIA; I. D. BIANCO; H. TRÍBULO; R. TRIBULO; M. FERRO SEOANE; S. FAUDONE; S.L. CUFFINI; N.A. DEMICHELIS; H. SCHALLIOL; D.M. BELTRAMO

ELSEVIER SCIENCE BV

Año: 2009 vol. 382 p. 98 - 98

Latex, a polyisoprene (PI) hydrophobic elastormer was evaluated in vitro and in vivo as a matrix for intravaginal steroid hormone delivery. Hormone containing matrices were prepared by swelling latex in chloroform containing soluble progesterone (P4). In vitro studies demonstrate that P4 release from PI follows a zero order model during at least 100 h and depends on initial load up to 10 mg.cm-2. Release of P4 from a PI matrix was found to be two times higher than from a polydimethylsiloxane (PDMS) matrix. FT-IR and X-Ray powder diffraction analysis of P4 polymorphs show that on PDMS the hormone crystallizes only in α-form while on latex crystallizes as a mixture of α-form and β-form. In vivo studies show that devices with a PI matrix