Helminth antigens and CpG-treated dendritic cells inhibit the symptoms of collagen-induced arthritis through the generation of Foxp3+ regulatory T cells

F. CARRANZA; C. FALCÓN; N. NUÑEZ; S.G. CORREA; I.D. BIANCO; M. MACCIONI; R. FRETES; M.F. TRIQUEL; C. MOTRAN; L. CERVI

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2012 vol. 7 p. 1 - 1

font size="1" face="AdvP403A40"> Dendritic cells (DC) have the potential to control the outcome of autoimmunity by modulating the immune response. In this study, we tested the ability of Fasciola hepatica total extract (TE) to induce tolerogenic properties in CpG-ODN (CpG) maturated DC, to then evaluate the therapeutic potential of these cells to diminish the inflammatory response in collagen induced arthritis (CIA). DBA/1J mice were injected with TE plus CpG treated DC (T/C-DC) pulsed with bovine collagen II (CII) between two immunizations with CII and clinical scores CIA were determined. The levels of CII-specific IgG2 and IgG1 in sera, the histological analyses in the joints, the cytokine p