Resumen:
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The antiviral effects of the cationic acrylate polymer E100 on a panel of lipid-enveloped viruses
and the interactions involved are studied. The treatment of several common viruses with E100
induced a dose-dependent inhibition of the infectivity of viruses below the detection limit of
the assays employed. Similarly, the treatment of
human sera infected with HIV or HCV reduced
virus RNA plasma levels to undetectable values.
This implies that Eudragit E100 can interact
with enveloped viruses, even in the presence
of proteins, through a mechanism that is not
reversed by titration of the positively charged
groups of the polymer, opening the possibility
to remove viral parti