Amphipathic and membrane-destabilizing properties of the cationic acrylate polymer Eudragit E100

R.V. ALASINO; S.F. AUSAR; I.D. BIANCO; L.F. CASTAGNA; M. CONTIGIANI; D.M. BELTRAMO

Wiley-VCH

Lugar: Hoboken; Año: 2005 vol. 5 p. 203 - 203

p style="margin: 0cm 0cm 0pt; line-height: 200%; text-align: justify;" class="MsoNormal">The cationic acrylate polymer Eudragit E100 (E100) produces a biphasic effect on the stability of casein micelles disrupting their internal structure (S.F. Ausar, et al., J.Agric.Food Chem.2003, 51, 4417). These results suggested that this polymer could have some amphipathic character. Therefore, in this study the polymer was characterized with respect to its interaction with different amphipathic systems (bile-acid micelles, lipoproteins and liposomes), cell membranes (red blood cells)  and virus membranes (Herpes simplex type 2 virus). As with caseins, a biphasic effect was observed with bile acids with a precipitation phase at low polymer/bile acid ratio and a solubilization phase when the polymer concentration was increased. Upon interaction with human plasma, an important reduction in cholesterol and triglycerides was obs