Nitric oxide-mediated apoptosis in rat macrophages subjected to shiga toxin from Escherichia coli.

BARONETTI JL; ANGEL VILLEGAS, N; PARAJE, MG; ALBESA I

WILEY-BLACKWELL PUBLISHING, INC

Año: 2011 vol. 55 p. 231 - 231

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify; mso-layout-grid-align: none">Shiga toxin-producing Escherichia coli are important food-borne pathogens. The main  virulence factor of this bacterium is its capacity to secrete Shiga toxins (Stxs), which have  been reported to induce apoptosis in several cell types. However, the mechanisms of this  apoptosis have not yet been fully elucidated. In addition, Stxs have also been shown to  stimulate macrophage to produce nitric oxide (NO), a well-known apoptosis inductor. The