Heat-Killed cells of Cryptococcus neoformans var grubii induces protective immunity in rats: immunological ans histopathological parameters

BARONETTI JL, CHIAPELLO LS, AOKI MP, GEA S, AND MASIH DT

MEDICAL MYCOLOGY

Taylor and Francis

Lugar: Nueva York. USA; Año: 2006 vol. 44 p. 493 - 493

1369-3786

font face="AdvTR" size="3"> Different clinical parameters which included cell-mediated immune (CMI) response, were evaluated in a model of disseminated cryptococcosis in rats. The experimental animals were pretreated four days prior to their exposure to Cryptococcus neoformans var. grubii with either heat killed cells of this yeastlike pathogen (HKC) or capsular polysaccharide (CPS) emulsified in complete Freund adjuvant (CFA). Rats treated with HKC-CFA and intraperitoneally infected with C. neoformans var. grubii had significantly better clearance of yeasts from tissues, a lower concentration of the cryptococcal capsular polysaccharide, glucuronoxylomannan (GXM), in serum and tissues, and better his